PDE9-IN-1 is a potent, selective, and orally bioavailable phosphodiesterase-9A (PDE9A) Inhibitor with an IC50 of 8.7 nM.

Product information

CAS Number: 2305087-92-5

Molecular Weight: 362.40

Formula: C17H23FN6O2

Chemical Name: 1-cyclopentyl-6-{[(2R)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxopropan-2-yl]amino}-1H,4H,5H-pyrazolo[3,4-d]pyrimidin-4-one

Smiles: C[C@@H](NC1NC(=O)C2C=NN(C3CCCC3)C=2N=1)C(=O)N1C[C@@H](F)CC1

InChiKey: HOQGZKUBNCAZBE-MNOVXSKESA-N

InChi: InChI=1S/C17H23FN6O2/c1-10(16(26)23-7-6-11(18)9-23)20-17-21-14-13(15(25)22-17)8-19-24(14)12-4-2-3-5-12/h8,10-12H,2-7,9H2,1H3,(H2,20,21,22,25)/t10-,11+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PDE9-IN-1 is excellent selectivity across PDE families.

In Vivo:

PDE9-IN-1 (2.5 and 5.0 mg/kg; Oral administration; daily for 21 days) effectively recovers learning and memory function.

Products are for research use only. Not for human use.