CD207 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES4005-50, ES4005-100

Citations, Manuals and MSDS Available upon request.

Background: The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity. [provided by RefSeq, Aug 2010],

Alternate Name: CD207; CLEC4K; C-type lectin domain family 4 member K; Langerin; CD207

Source: Rabbit

Applications: WB; ELISA

Dilution: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Rat; Mouse;

Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human CD207. AA range:61-110

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 38kD

Human Gene ID: 50489

Human SWISS Prot NO: Q9UJ71

Subcellular Location: Membrane; Single-pass type II membrane protein. Found in Birbeck granules (BGs), which are organelles consisting of superimposed and zippered membranes.

Research Use Only