Recombinant Rhesus Macaque ICOS/AILIM/CD278 Protein (Fc Tag)

Sizes: 10μg, 50μg

Catalogue Numbers: PKSQ050074-10, PKSQ050074-50

Citations, Manuals and MSDS Available upon request.

Abbreviation: ICOS; AILIM; CD278

Target Synonym: Inducible T-cell costimulator; activation-inducible lymphocyte immunomediatory molecule; CD278; AILIM; CVID1; ICOS

UNIProt ID: H9Z062

Target Species: Rhesus macaque

Expression Host: HEK293 Cells

Fusion Tag: C-Fc

Accession: H9Z062

Background: Inducible T-cell costimulator, also known as activation-inducible lymphocyte immunomediatory molecule, CD278, AILIM, CVID1 and ICOS, belongs to the CD28 and CTLA4 cell surface receptor family.. ICOS contains one Ig-like V-type domain and exsits as a homodimer with disulfide-linked. ICOS is highly expressed on tonsillar T-cellsand can be induced by PMA and ionomycin, ICOS plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. Defects in ICOS are the cause of immunodeficiency common variable type 1, which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antige.

Sequence: Gly20-Lys140

Purity: > 90 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 40.8 kDa

Observed MW: 50-60 kDa

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Research Use Only