Ref-1 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA29326-50, RA29326-100 Citations, Manuals and MSDS Available upon request. Background: apurinic/apyrimidinic endodeoxyribonuclease 1 (APEX1) Homo sapiens Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq, Jul 2008], Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications. Alternative Names: APEX1; APE; APE1; APEX; APX; HAP1; REF1; DNA- (apurinic or apyrimidinic site) lyase; APEX nuclease; APEN; Apurinic-apyrimidinic endonuclease 1; AP endonuclease 1; APE-1; REF-1; Redox factor-1 Applications: WB; IHC-p; IF (paraffin section) ; ELISA Species Cross-Reactivity: Human; Mouse; Rat GeneID (Human): 328 Protein MW (KDa): 34 SWISS: P27695 Source: Rabbit Research Use Only