N-Acetyl-D-cysteine has antioxidant activities and scavenges ROS through the reaction with its thiol group, but cannot enter the glutathione metabolic pathway.

Product information

CAS Number: 26117-28-2

Molecular Weight: 163.19

Formula: C5H9NO3S

Chemical Name: (2S)-2-acetamido-3-sulfanylpropanoic acid

Smiles: CC(=O)N[C@H](CS)C(O)=O

InChiKey: PWKSKIMOESPYIA-SCSAIBSYSA-N

InChi: InChI=1S/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : 250 mg/mL (1531.96 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

N-Acetyl-D-cysteine (20 mM; 1 hour pretreatment; 12 hours) does not increase intracellular GSH levels, but GSH monoester does. D-NAC can not enhance hypoxic apoptosis. This demonstrate that GSH rather than D-NAC or NAC is responsible for enhancing hypoxic apoptosis.

References:

1. Maika Deffieu, et al. Glutathione Participates in the Regulation of Mitophagy in Yeast.J Biol Chem. 2009 May 29;284(22):14828-37.
2. B K Wong,et al. Selective Effects of N-acetylcysteine Stereoisomers on Hepatic Glutathione and Plasma Sulfate in Mice. Toxicol Appl Pharmacol
3. Suparna Qanungo, et al. N-Acetyl-L-cysteine Enhances Apoptosis Through Inhibition of Nuclear factor-kappaB in Hypoxic Murine Embryonic Fibroblasts. J Biol Chem

Products are for research use only. Not for human use.