Cantharidic acid, an inhibitor of protein phosphatases, is first isolated from Chinese blister beetles. Cantharidic acid is a hydrolysis product of cantharidin. Protein phosphatases, account for virtually all of the phosphatase activity toward phosphoproteins, have been involved in controlling glycogen metabolism, glycolysis, gluconeogenesis, fatty acid synthesis, cholesterol synthesis, and protein synthesis. Protein phosphatases participate in protein phosphorylation, a principal regulatory mechanism in the control of almost all cellular processes . In vitro: Cantharidic acid exihibited inhibitory effects on the protein phosphatases PP1 and PP2A with IC50 values of 0.6 and 0.05 μM, respectively. Cantharidic acid showed no effect on the activity of PP2B or PP2C . In vivo: Intraperitoneal administration of cantharidic acid (10 mg/kg) to mice for 45 min caused extreme liver enlargement and congestion. Treatment with cantharidic acid increased hepatic glycogenolysis, elevated blood glucose and hepatic glycogen phosphorylase levels, reduced hepatic glycogen content and glycogen synthase activity. Cantharidic acid endothal decreased microsomal Mg2+-ATPase levels .

Product information

CAS Number: 1465-77-6

Molecular Weight: 260.19

Formula: C10H14Na2O5

Chemical Name: disodium (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid

Smiles: [Na+].[Na+].C[C@]1([C@H]2CC[C@H](O2)[C@]1(C)C(O)=O)C(O)=O

InChiKey: JFALSOLNDKMHAL-CSYCBQNYSA-N

InChi: InChI=1S/C10H14O5.2Na/c1-9(7(11)12)5-3-4-6(15-5)10(9,2)8(13)14;;/h5-6H,3-4H2,1-2H3,(H,11,12)(H,13,14);;/q;2*+1/t5-,6+,9+,10-;;

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.