Bcl-Xl Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA22359-50, RA22359-100

Citations, Manuals and MSDS Available upon request.

Background: BCL2 like 1 (BCL2L1) Homo sapiens The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: IHC: 1:50-1:200

Alternative Names: Bcl-2-like protein 1 (Bcl2-L-1;Apoptosis regulator Bcl-X)

Applications: IHC-p; IF (paraffin section)

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 598

Protein MW (KDa): 30

SWISS: Q07817

Source: Rabbit

Research Use Only