Propargyl-PEG6-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Product information

CAS Number: 1355197-95-3

Molecular Weight: 404.50

Formula: C20H36O8

Chemical Name: tert-butyl 4,7,10,13,16,19-hexaoxadocos-21-ynoate

Smiles: CC(C)(C)OC(=O)CCOCCOCCOCCOCCOCCOCC#C

InChiKey: QNWQLRBFWIUOKY-UHFFFAOYSA-N

InChi: InChI=1S/C20H36O8/c1-5-7-22-9-11-24-13-15-26-17-18-27-16-14-25-12-10-23-8-6-19(21)28-20(2,3)4/h1H,6-18H2,2-4H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

References:

1. Noah Bell, et al. Compounds and methods for inhibiting phosphate transport. WO2012054110A2.

Products are for research use only. Not for human use.