PNP Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS7855-50, BS7855-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P00491

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB IP

All Applications: WB 1:500 - 1:2000
IP 1:50 - 1:100

Background: Purine nucleoside phosphorylase (PNP), also designated inosine phosphorylase, forms a homotrimer. It belongs to the PNP/MTAP phosphorylase family of proteins. Human PNP catalyzes the reversible phosphorolysis of ribonucleosides and 2’-deoxyribonucleosides with specificity for guanine, hypoxanthine, and their analogs. PNP deficiency is a rare autosomal recessive genetic disease associated with a severe defect in T-lymphocyte function and neurologic disorder in children, comprising four percent of combined immunodeficiency cases. Children with PNP deficiency are highly prone to infections, autoimmune disorders, neurological impairment, and cancer.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: NP polyclonal antibody detects endogenous levels of NP protein.

Bioworld Molecular Weight: ~ 31 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot (WB) analysis of NP polyclonal antibody

Alternative Name: Inosine phosphorylase;
Inosine-guanosine phosphorylase;
MGC117396;
MGC125915;
MGC125916;
NP;
Np1;
Nucleoside phosphorylase;
PNP;
Pnp1;
PNPH_HUMAN;
PRO1837;
PUNP;
Purine nucleoside orthophosphate ribosyltransferase;
Purine nucleoside phosphorylase 5a;
Purine nucleoside phosphorylase;

Immunogen: Recombinant full length Human NP.

Conjugate: Unconjugated

Modification: Unmodified