Dok-7 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES5609-50, ES5609-100

Citations, Manuals and MSDS Available upon request.

Background: docking protein 7 (DOK7) Homo sapiens The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009],

Alternate Name: DOK7; C4orf25; Protein Dok-7; Downstream of tyrosine kinase 7

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Mouse

Immunogen: The antiserum was produced against synthesized peptide derived from human DOK7. AA range:10-59

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 60kD

Human Gene ID: 285489

Human SWISS Prot NO: Q18PE1

Subcellular Location: Cell membrane; Peripheral membrane protein. Cell junction, synapse. Accumulates at neuromuscular junctions.

Research Use Only