Propargyl-PEG11-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG11-amine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product information

Molecular Weight: 539.66

Formula: C25H49NO11

Chemical Name: 3,6,9,12,15,18,21,24,27,30,33-undecaoxahexatriacont-35-yn-1-amine

Smiles: C#CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN

InChiKey: QJITZAWTLZAIGR-UHFFFAOYSA-N

InChi: InChI=1S/C25H49NO11/c1-2-4-27-6-8-29-10-12-31-14-16-33-18-20-35-22-24-37-25-23-36-21-19-34-17-15-32-13-11-30-9-7-28-5-3-26/h1H,3-26H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.