Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO can suppress the production of mature IL-lβ.

Product information

CAS Number: 143313-51-3

Molecular Weight: 492.52

Formula: C23H32N4O8

Chemical Name: (3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-4-oxobutanoic acid

Smiles: CC(=O)N[C@@H](CC1C=CC(O)=CC=1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C=O

InChiKey: LPIARALSGDVZEP-SJVNDZIOSA-N

InChi: InChI=1S/C23H32N4O8/c1-12(2)20(23(35)24-13(3)21(33)26-16(11-28)10-19(31)32)27-22(34)18(25-14(4)29)9-15-5-7-17(30)8-6-15/h5-8,11-13,16,18,20,30H,9-10H2,1-4H3,(H,24,35)(H,25,29)(H,26,33)(H,27,34)(H,31,32)/t13-,16-,18-,20-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Ac-YVAD-CHO inhibits IL-1β in a dose-dependent manner, with mouse and human IC50 values of 2.5 and 0.7 μM. Ac-YVAD-CHO (0.01~100 μM) reduces the elevations of IL-lβ in the plasma and peritoneal fluid treated with LPS in a dose-related manner.

In Vivo:

Ac-YVAD-CHO (10 mg/kg; i.p.; 1 hour) is absorbed from the peritoneal cavity, as well as cleared from the blood rapidly. Ac-YVAD-CHO (50 mg/kg; i.p.; 1 hour) drops precipitously to approximately 1 and 0.2 μM at 30 and 60 minutes after injection. Ac-YVAD-CHO (30 mg/kg; i.p.; 6 hours) suppresses IL-1β levels.

Products are for research use only. Not for human use.