Benocyclidine is an inhibitor of dopamine reuptake [1, 2]. Dopamine plays important roles in the brain and body. In the brain, dopamine functions as a neurotransmitter involved in reward-motivated behavior, motor control and controlling the release of various hormones. Dysfunctions of the dopamine system have been associated several important diseases including Parkinson's disease, attention deficit hyperactivity disorder, schizophrenia, and addiction . Dopamine also functions in blood vessels, kidneys, pancreas, the digestive system, the immune system, and the blood vessels. Benocyclidine (BTCP) was a derivative of phencyclidine (PCP) with a benzothiophenyl group instead of a phenyl ring. BTCP potently inhibited dopamine (DA) uptake with the IC50 of 7-8 nM. BTCP showed low affinity for the PCP receptor with the IC50 of 6 μM [1, 2]. In the striatum, BTCP binding was dose-dependently inhibited by unlabeled BTCP and nomifensine with the ID50 of 6.34 mg/kg and 11.06 mg/kg, respectively. BTCP bound to the dopamine uptake complex in the mouse brain in vivo .

Product information

CAS Number: 112726-66-6

Molecular Weight: 299.47

Formula: C19H25NS

Chemical Name: 1-[1-(1-benzothiophen-2-yl)cyclohexyl]piperidine

Smiles: C1CCCCN1C1(CCCCC1)C1=CC2=CC=CC=C2S1

InChiKey: RGSVXQJPSWZXOP-UHFFFAOYSA-N

InChi: InChI=1S/C19H25NS/c1-5-11-19(12-6-1,20-13-7-2-8-14-20)18-15-16-9-3-4-10-17(16)21-18/h3-4,9-10,15H,1-2,5-8,11-14H2

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.