m-PEG12-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 1620461-89-3

Molecular Weight: 623.57

Formula: C25H51BrO12

Chemical Name: 37-bromo-2,5,8,11,14,17,20,23,26,29,32,35-dodecaoxaheptatriacontane

Smiles: COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCBr

InChiKey: PRKRQHNXAMEUPI-UHFFFAOYSA-N

InChi: InChI=1S/C25H51BrO12/c1-27-4-5-29-8-9-31-12-13-33-16-17-35-20-21-37-24-25-38-23-22-36-19-18-34-15-14-32-11-10-30-7-6-28-3-2-26/h2-25H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.