PS-1 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA29044-50, RA29044-100 Citations, Manuals and MSDS Available upon request. Background: presenilin 1 (PSEN1) Homo sapiens Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP) . These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains) . Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008], Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications. Alternative Names: PSEN1; AD3; PS1; PSNL1; Presenilin-1; PS-1; Protein S182 Applications: WB; IHC-p; IF (paraffin section) ; ELISA Species Cross-Reactivity: Human; Rat; Mouse GeneID (Human): 5663 Protein MW (KDa): 60 SWISS: P49768 Source: Rabbit Research Use Only