CDK7 (Phospho-T170) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS64520-50, BS64520-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P50613

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB, IHC

All Applications: WB:1:500~1:1000 IHC:1:50~1:200

Background: Cdk7 is a member of the cyclin dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. Cdk7 forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: CDK7 (Phospho-T170) polyclonal antibody detects endogenous levels of CDK7 protein only when phosphorylated at Thr170.

Bioworld Molecular Weight: ~ 40 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of CDK7 (Phospho-T170) polyclonal antibody at 1:500 dilution
Lane A: Hela whole cell lysate
Lane B: HEK293T whole cell lysate
Lane C: A549 whole cell lysate
Lane D: MCF-7 whole cell lysate
Lane E: Raw264.7 whole cell lysate
Lane F: The Spleen tissue lysate of Mouse

Alternative Name: Cyclin-dependent kinase 7; 39 kDa protein kinase; p39 Mo15; CDK-activating kinase 1; Cell division protein kinase 7; Serine/threonine-protein kinase 1; TFIIH basal transcription factor complex kinase subunit; CDK7; CAK; CAK1; CDKN7; MO15; STK1

Immunogen: Synthetic phosphopeptide derived from human CDK7 around the phosphorylation site of Threonine 170.

Conjugate: Unconjugated

Modification: Phosphorylation