Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC50 of 0.1 μM for mushroom tyrosinase.

Product information

CAS Number: 855746-98-4

Molecular Weight: 456.53

Formula: C26H32O7

Chemical Name: (2S)-2-(2,4-dihydroxyphenyl)-7-hydroxy-8-[(2R)-5-hydroxy-5-methyl-2-(prop-1-en-2-yl)hexyl]-5-methoxy-3,4-dihydro-2H-1-benzopyran-4-one

Smiles: CC(=C)[C@H](CCC(C)(C)O)CC1=C(O)C=C(OC)C2C(=O)C[C@H](OC=21)C1=CC=C(O)C=C1O

InChiKey: XMUPAAIHKAIUSU-QRQCRPRQSA-N

InChi: InChI=1S/C26H32O7/c1-14(2)15(8-9-26(3,4)31)10-18-20(29)12-23(32-5)24-21(30)13-22(33-25(18)24)17-7-6-16(27)11-19(17)28/h6-7,11-12,15,22,27-29,31H,1,8-10,13H2,2-5H3/t15-,22+/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Kurarinol manifests relatively low cytotoxic activity (EC50>30 μM). Kurarinol inhibits production of melanin in S. bikiniensis without affecting the growth of microorganism. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling (STAT3).

In Vivo:

Kurarinol (20 mg/kg; p.o.; daily; for 3 days) reduces serum lipid levels in high-Cholesterol diet induced hyperlipidemic rats.

Products are for research use only. Not for human use.