Science-Based Nutrition Helps Supports Mood and Neural Function Helps Supports Joint Comfort and Mobility Helps Supports Liver Health and Detoxification Vegetarian Dietary Supplement Non-GMO Gluten Free Soy Free Doctor's Best SAM-e helps replenish your SAM-e levels and promote a healthy mood. SAM-e (S-Adenosyl-L-Methionine) is naturally produced by your body and helps maintain healthy emotions. Various factors such as diet and aging can cause low levels of SAM-e, leaving you feeling unbalanced and moody. Supplementing with SAM-e Soloesse Italian SAM-e is processed to yield the highest available percentage of the active pure S,S form which helps mediate biochemical activity in the human body. SAM-e and Mood and Cognitive Function SAM-e helps facilitate DNA enzymatic actions. These enzymatic actions are required for the healthy conversion of neurotransmitters responsible for healthy emotions, such a serotonin and dopamine. SAM-e also facilitates glutathione usage which improves the body's antioxidant defense and helps maintain acetylcholine levels necessary for cognitive function. SAM-e and Joint Function In clinical trials, SAM-e has been shown to help increase joint comfort and mobility by promoting the synthesis of proteoglycans, essential components of connective tissue. SAM-e and Liver Function SAM-e helps support healthy levels of glutathione, a critical antioxidant which helps protect against free radicals. SAM-e acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health. Doctor's Best utilizes only the highest quality Italian Soloesse SAM-e providing slow and targeted release for improved GI tolerance and absorption. Our Double-Strength SAM-e 400 contains 400 mg of active Soloesse SAM-e in each tablet. This ensures that you receive the most potent SAM-e product with the highest percentage of the active S,S form per serving.