Aggrecan Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90037-50, BS90037-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P16112(Human) P07897(Rat)

Host: Rabbit

Reactivity: Human, Rat

Applications: WB,

All Applications: WB 1:500 - 1:2000

Background: The large chondroitin sulfate proteoglycan, aggrecan, is the predominant proteoglycan present in cartilage. Aggrecan is a member of the chondroitin sulphate proteoglycan family, which also includes versican/PG-M, neurocan and brevican. Aggrecan is a complex multidomain macromolecule that undergoes extensive processing and post-translational modification. Aggrecan in cartilage forms aggregates with hyaluronan and link protein, embedded in a collagen network. Aggrecan accounts for the compressive stiffness and resilience of the hyaline cartilage. Many forms of inflammatory arthritis are shown to be accompanied with aggrecan degradation and loss from the cartilage. Brevican is a brain proteoglycan of the aggrecan/versican/neurocan family. In the adult brain, the brevican core protein undergoes proteolytic cleavage and exists as a full-length form a carboxy-terminal fragment and an amino-terminal fragment.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Aggrecan polyclonal antibody detects endogenous levels of Aggrecan protein.

Bioworld Molecular Weight: 250/246/239 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemical analysis of paraffin-embedded rat cartilage tissue using anti-Aggrecan antibody. Counter stained with hematoxylin., Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Aggrecan antibody. Counter stained with hematoxylin.

Alternative Name: CSPCP, Chondroitin sulfate proteoglycan 1, ACAN, AGC1, CSPG1, MSK16, ACAN, AGC 1, AGC1, AGCAN, Aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal, A0122), Aggrecan 1, Aggrecan core protein, Aggrecan proteoglycan, Aggrecan structural proteoglycan of cartilage, Aggrecan1, ATEGQV, Cartilage specific proteoglycan core protein, Chondroitin sulfate proteoglycan 1, Chondroitin sulfate proteoglycan 1 large aggregating proteoglycan antigen identified by monoclonal, A0122, Chondroitin sulfate proteoglycan core protein 1, CSPG 1, CSPG1, CSPGCP, JSCATE, Large aggregating proteoglycan, mcspg, mgsk16, MSK 16, MSK16, SEDK,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified