IC50: 140 nM ML-354 is an indole-based, proteinase-activated receptor (PAR) 4 antagonist with good potency and reasonable selectivity versus PAR1. PARs are a family of four G-protein-coupled receptors GPCRs (PAR1-PAR4) with several unique attributes, which are activated by serine proteases. The activation of PARs needs a unique mechanism which requiring proteolysis unmasking their extracellular N-terminal domain. PAR4 is a thrombin receptor found on human platelets and represents a potential therapeutic target for the treatment of thrombotic disorders . In vitro: Up to now, in vitro study of ML-354 is still in the development stage. In vivo: Up to now, in vivo study of ML-354 is still in the development stage.

Product information

CAS Number: 89159-60-4

Molecular Weight: 282.29

Formula: C16H14N2O3

Chemical Name: (1-methyl-5-nitro-3-phenyl-1H-indol-2-yl)methanol

Smiles: CN1C(CO)=C(C2C=C(C=CC1=2)[N+]([O-])=O)C1C=CC=CC=1

InChiKey: GNJUKVGDCUKDLF-UHFFFAOYSA-N

InChi: InChI=1S/C16H14N2O3/c1-17-14-8-7-12(18(20)21)9-13(14)16(15(17)10-19)11-5-3-2-4-6-11/h2-9,19H,10H2,1H3

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.