IL-4R/CD124(Phospho-Y497) Polyclonal Antibody

Catalogue Numbers: AP0132-50, AP0132-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.4.

Swiss-Prot: P24394

Host: Rabbit

Reactivity: Human

Applications: WB

All Applications: WB: 1:500~1:1000

Background: The armadillo (ARM) repeat family of proteins are related to the Drosophilamelanogaster armadillo protein, a protein essential for wingless signal transduction. ARM proteins are involved in a variety of processes such as cellmigration, cell proliferation, tissue maintenance and tumorigenesis. They areintracellular proteins and function in signal transduction and cell structure.
ARMCX3 (armadillo repeat containing, X-linked 3), also known as ALEX3(ARM protein lost in epithelial cancers on chromosome X 3), is a single passmembrane protein belonging to the armadillo repeat family of proteins.ARMCX3 contains three ARM repeats and shares 60% sequence similaritywith the related proteins, ARMCX1 and ARMCX2. ARMCX3 is believed toplay a role in embryonic development and tissue maintenance and may alsofunction as a tumor suppressor.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: IL-4R/CD124(Phospho-Y497) polyclonal antibody detects endogenous levels of IL-4R/CD124 protein only when phosphorylated at Tyr497.

Extra Notes: Western blot (WB) analysis of IL-4R/CD124(Phospho-Y497) polyclonal antibody at 1:500 dilution
Lane1:MCF-7 whole cell lysate(40ug)
Lane2:HCT116 whole cell lysate(40ug)
Lane3:SGC7901 whole cell lysate(40ug)

Bioworld Molecular Weight: ~ 78 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Interleukin-4 receptor subunit alpha; IL-4 receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD_antigen: CD124; Soluble IL-4 receptor subunit alpha; Soluble IL-4R-alpha; sIL4Ralpha/prot; IL-4-binding protein; IL4-BP; IL4R; 582J2.1

Immunogen: Synthetic phosphopeptide derived from human IL-4R/CD124 around the phosphorylation site of Tyrosine 497.

Conjugate: Unconjugated

Modification: Phosphorylation