Recombinant Human IMPA2/IMPase 2 Protein (His Tag)

Sizes: 10μg, 50μg

Catalogue Numbers: PKSH032591-10, PKSH032591-50

Citations, Manuals and MSDS Available upon request.

Abbreviation: IMPA2; IMPase 2

Target Synonym: Inositol Monophosphatase 2; IMP 2; IMPase 2; Inositol-1(or 4)-Monophosphatase 2; Myo-Inositol Monophosphatase A2; IMPA2; IMP.18P

UNIProt ID: O14732

Research Areas: Signal Transduction; Neuroscience; Cancer; metabolism;

Target Species: Human

Expression Host: E.coli

Fusion Tag: N-6His

Accession: O14732

Background: Inositol monophosphatase 2, also known as Inositol-1(or 4)-monophosphatase 2, Myo-inositol monophosphatase A2 and IMPA2, is an enzyme which belongs to the inositol monophosphatase family. IMPA2 catalyzes the dephosphoylration of inositol monophosphate with cofactor Magnesium and Inhibited by high Li+ and restricted Mg2+ concentrations. IMPA2 plays an important role in phosphatidylinositol signaling. IMPA2 can use the myo-inositol monophosphates, scylloinositol 1, 4-diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. IMPA2 is a pharmacological target for lithium Li(+) action in brain, it is considered to have a role in schizophrenia and bipolar disorder.

Sequence: Met 1-Lys288

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, 2mM DTT, pH 8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 33.5 kDa

Observed MW: 30 kDa

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Research Use Only