Recombinant Human IL3RA/CD123 Protein (Fc & Avi Tag)

Sizes: 20μg, 100μg

Catalogue Numbers: PKSH033800-20, PKSH033800-100

Citations, Manuals and MSDS Available upon request.

Abbreviation: IL3RA; CD123

Target Symptom: Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunitalpha; IL-3R-alpha; IL-3RA

Research Area: Signal Transduction; immunology;

Conjugation: Biotinylated

Target Species: Human

Expression Host: HEK293 Cells

Fusion Tag: C-Fc-Avi

UNIProt ID: P26951

Accession: P26951

Background: CD123; also known as Interleukin-3 receptor subunit alpha; belongs to the type I cytokine receptor family. In mouse; there are two classes of high-affinity IL3 receptors. One contains an IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors. CD123 stimulates the proliferation and differentiation of hemopoietic cells including the pluripotent hematopoietic stem cells as well as various lineage committed cells. CD123 is a heterodimer consisting of an alpha and a beta subunit. The alpha subunit alone binds IL 3 with low affinity. The beta subunit does not bind IL 3 by itself but is required for the high affinity binding of IL 3 to the heterodimeric receptor complex.

Sequence: Thr19-Arg305

Purity: > 90 % as determined by reducing SDS-PAGE.

Formulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Please refer to the printed manual for detailed information.

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 61.8 kDa

Observed MW: 80-100 kDa

Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

Shipping: This product is provided as lyophilized powder which is shipped with ice packs.

Research Use Only