TT2-32, also known as TLN-232 and CAP232, is a somatostatin structural derivative with antitumor activity. TT-232 inhibited tyrosine kinase activity of tumor cell lines and this inhibition correlated well with the inhibition of cell proliferation of a large number of cancer cell lines in vitro and reduces the size of different tumors in animal models in vivo. The antitumor efficacy of TT-232 has been found to be associated with the induction of apoptosis in tumor cells, resulting in highly selective elimination of tumor tissue. TT-232 was found to be devoid of GH release inhibitory activity but to possess strong antitumor effects. It binds with a high affinity to SSTR1 and SSTR4. This compound was also found to inhibit inflammation in a number of experimental models.

Product information

Molecular Weight: 1007.19

Formula: C47H62N10O11S2

Chemical Name: (4R, 7S, 10R, 13S, 16R)-10-((1H-indol-3-yl)methyl)-N-((2S, 3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)-16-((R)-2-amino-3-phenylpropanamido)-7-(4-aminobutyl)-13-(4-hydroxybenzyl)-6, 9, 12, 15-tetraoxo-1, 2-dithia-5, 8, 11, 14-tetraazacycloheptadecane-4-carboxamide acetate

Smiles: CC(O)=O.C[C@@H](O)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](N)CC2C=CC=CC=2)C(=O)N[C@@H](CC2=CC=C(O)C=C2)C(=O)N[C@H](CC2=CNC3=CC=CC=C23)C(=O)N[C@@H](CCCCN)C(=O)N1)C(N)=O

InChiKey: DPXYLBGOBOVJQG-YWCUHKGISA-N

InChi: InChI=1S/C45H58N10O9S2.C2H4O2/c1-25(56)38(39(48)58)55-45(64)37-24-66-65-23-36(53-40(59)31(47)19-26-9-3-2-4-10-26)44(63)51-34(20-27-14-16-29(57)17-15-27)42(61)52-35(21-28-22-49-32-12-6-5-11-30(28)32)43(62)50-33(41(60)54-37)13-7-8-18-46;1-2(3)4/h2-6,9-12,14-17,22,25,31,33-38,49,56-57H,7-8,13,18-21,23-24,46-47H2,1H3,(H2,48,58)(H,50,62)(H,51,63)(H,52,61)(H,53,59)(H,54,60)(H,55,64);1H3,(H,3,4)/t25-,31-,33+,34+,35-,36+,37+,38+;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: To be determined

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Varona L, Noguera JL, Casellas J, de Hijas MM, Rosas JP, Ibáñez-Escriche N. A cross-specific multiplicative binomial recursive model for the analysis of perinatal mortality in a diallel cross among three varieties of Iberian pig. Sci Rep. 2020 Dec 3;10(1):21190. doi: 10.1038/s41598-020-78346-7. PMID: 33273670; PMCID: PMC7712833.
2. Sun C, Liu M, Zhang W, Wang S, Qian G, Wang M, Zhang G. Overexpression of enolase 2 is associated with worsened prognosis and increased glycikolysis in papillary renal cell carcinoma. J Cell Physiol. 2021 May;236(5):3821-3831. doi: 10.1002/jcp.30130. Epub 2020 Nov 1. PMID: 33135164.
3. Jung Y, Oh SH, Witek RP, Petersen BE. Somatostatin stimulates the migration of hepatic oval cells in the injured rat liver. Liver Int. 2012 Feb;32(2):312-20. doi: 10.1111/j.1478-3231.2011.02642.x. Epub 2011 Sep 14. PMID: 22098068; PMCID: PMC3253984.

Products are for research use only. Not for human use.