PSD-93 Polyclonal Antibody

Catalogue Numbers: BS5868-50, BS5868-100

Sizes: 50µl, 100µl

Alternative Name: Disks large homolog 2; Channel-associated protein of synapse-110; Chapsyn-110; Chapsyn110; Chapsyn 110; Postsynaptic density protein PSD-93; PSD93; DLG2

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q15700

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB ICC

All Applications: WB: 1:500~1:1000
ICC: 1:50~1:200

Background: The postsynaptic density protein (PSD)-93 and related membrane associated guanylate kinase (MAGUK) proteins assemble signal transduction complexes at sites of cell-cell contact including synapses. PSD-93 (also designated channel associated protein of synapse-110 or chapsyn-110) occurs only at postsynaptic sites in hippocampal neurons. PSD-95 and PSD-93 mediate ion channel clustering in heterologous cells and are believed to cluster and anchor NMDA receptors at the synapse. The glutamate receptor subunit, delta2, binds specifically to PSD-93, which is enriched in Purkinje neuron cell bodies and dendrites. In addition, PSD-93 clusters delta2 when they are coexpressed and they are colocalized at parallel fiber synapses.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: PSD-93 polyclonal antibody detects endogenous levels of PSD-93 protein.

Bioworld Molecular Weight: ~ 110 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot (WB) analysis of PSD-93 polyclonal antibody at 1:500 dilution
Lane 1: Hela cell lysate
Lane 2: NIH-3T3 cell lysate
Lane 3: PC12 cell lysate

Immunogen: Synthetic peptide, corresponding to amino acids 647-692 of Human PSD-93.

Conjugate: Unconjugated

Modification: Unmodified