HCAR2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES11652-50, ES11652-100

Citations, Manuals and MSDS Available upon request.

Background: developmental stage:Expression in neutrophils occurs in the late terminal differentiation phase., function:Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G (i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis., miscellaneous:The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide., similarity:Belongs to the G-protein coupled receptor 1 family., tissue specificity:Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils.,

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Reactivity: Human; Rat; Mouse;

Immunogen: Synthesized peptide derived from human protein . at AA range: 260-340

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 39kD

Human Gene ID: 338442

Human SWISS Prot NO: Q8TDS4

Subcellular Location: Cell membrane; Multi-pass membrane protein.

Research Use Only