KDM5B Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90766-50, BS90766-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9UGL1(Human) Q80Y84(Mouse)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: ICC IHC

All Applications: ICC:1:100-1:500
IHC:1:50-1:200

Background: PLU-1 is a large (1,544 amino acid) nuclear protein that interacts with brain factor-1 (BF-1) and paired box 9 (PAX9), both of which are developmental transcription factors. PLU-1 belongs to the testis-cancer antigen group of proteins and is a member of the ARID family of DNA binding proteins. It is a multi-domain protein with strong transcriptional repression properties. PLU-1 shows restricted expression in adult tissues, with high expression in testis and transient expression in the pregnant mammary gland. Both the PLU-1 gene and the PLU-1 protein product are specifically upregulated in breast cancer. PLU-1 may be important in meiotic transcription because of its apparent association with chromatin.

Purification and Purity: Peptide affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: KDM5B polyclonal antibody detects endogenous levels of KDM5B protein.

Bioworld Molecular Weight: 179 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: ICC staining KDM5B in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS., ICC staining KDM5B in PC-3M cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: CT31, RBP2-H1, KDM5B, JARID1B, PLU1, RBBP2H1, Cancer/testis antigen 31, CT31, Histone demethylase JARID1B, JARID1B, Jumonji AT rich interactive domain 1B, Jumonji/ARID domain-containing protein 1B, Kdm5b, KDM5B, Lysine (K) specific demethylase 5B, Lysine demethylase 5B, Lysine specific demethylase 5B, Lysine-specific demethylase 5B, PLU-1, PLU1, PPP1R98, Protein phosphatase 1 regulatory subunit 98, PUT1, putative DNA/chromatin binding motif, RBBP2H1A, RBP2 like, RBP2-H1, Retinoblastoma-binding protein 2 homolog 1, Retinoblastoma-binding protein 2 homolog 1A,

Immunogen: Peptide

Conjugate: Unconjugated

Modification: Unmodified