HGF Monoclonal Antibody

Catalogue Numbers: MB66884-50, MB66884-100

Sizes: 50µl, 100µl

Product: Mouse IgG1. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P14210

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: The Hepatocyte Growth Factor was initially discovered as a mitogenic cytokine that induced hepatocyte replication and proliferation . HGF is produced by stromal cells where it is processed by extracellular serine proteases into a heterodimer consisting of alpha and beta subunits .Through activation of its receptor, cMET, HGF has a wide range of effects beyond hepatocytes that includes angiogenesis, epithelial cell proliferation and morphogenesis, and tissue protection and regeneration . The HGF-cMET axis has been associated with several diseases, including cancer, where HGF has been shown to promote invasion, metastasis, and drug resistance . These research studies suggest that HGF is a potential diagnostic and therapeutic target.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of HGF protein.

Extra Notes: Western blot analysis of HGF expression in HepG2 (A), Ramos (B) whole cell lysates.

Bioworld Molecular Weight: ~ 85 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: HPTA; Hepatocyte growth factor; Hepatopoietin-A; Scatter factor; SF

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the center region of human HGF. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified