NLRC3 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90947-50, BS90947-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q7RTR2(Human) Q5DU56(Mouse)

Host: Rabbit

Reactivity: Human, Mouse

Applications: ICC, IHC, FC

All Applications: ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Background: Negative regulator of the innate immune response. Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) . May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination. Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells.

Purification and Purity: Peptide affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: NLRC3 polyclonal antibody detects endogenous levels of NLRC3 protein.

Bioworld Molecular Weight: 114 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: ICC staining NLRC3 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS., ICC staining NLRC3 in SH-SY5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: CLR16.2, NLRC3, NOD3, CARD15-like, CARD15-like protein, Caterpiller 16.2, Caterpiller protein 16.2, CLR16.2, FLJ00348, NLR family CARD domain containing 3, Nlrc3, NLRC3, NOD-like receptor C3, NOD3, NOD3 protein, Nucleotide-binding oligomerization domain protein 3, Nucleotide-binding oligomerization domain protein 3 caterpiller 16.2, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3, Protein NLRC3,

Immunogen: Peptide.

Conjugate: Unconjugated

Modification: Unmodified