IFN beta Monoclonal Antibody

Catalogue Numbers: MB66767-50, MB66767-100

Sizes: 50µl, 100µl

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P01574

Host: Mouse

Reactivity: Human

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: The genes encoding type I interferons (IFNs), which include 14 IFN-α genes, one IFN-β gene, one IFN-ω (also known as IFN-α II1) gene and a number of IFN-ω pseudogenes, are clustered on human chromosome 9. IFN-α and -β are cytokines that are widely known to induce potent antiviral activity. They exert a variety of other biological effects, including antitumor and immunomodulatory activities, and are increasingly used clinically to treat a range of malignancies, myelodysplasias and autoimmune diseases. IFN-ω is antigenically different from human IFN-α, IFN-β or IFN-g, but is a component of natural mixtures of IFN species produced by virus-induced leukocytes or Burkitt’s lymphoma cells. The type I interferon receptor (IFN-αR) interacts with IFN-α, IFN-β and IFN-ω, and seems to be a multisubunit receptor.

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of IFN beta protein.

Extra Notes: Western blot analysis of IFN beta expression in IFNB1 protein (A) whole cell lysates.

Bioworld Molecular Weight: ~ 24 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: IFB; IFNB; Interferon beta; IFN-beta; Fibroblast interferon

Immunogen: Recombinant fusion protein of human IFN beta. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified