Claudin 5 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90308-50, BS90308-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O00501(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, IHC

All Applications: WB:1:2,000-1:5,000
IHC:1:50-1:200

Background: The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and Junction adhesion molecule. Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands. Claudin expression is highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-5 is expressed in the endothelial junctions of the rat liver and in junctions of acinar cells of the pancreas. Human Claudin-5 is abundantly expressed in adult lung, heart and skeletal muscle and is deleted in patients with velocardiofacial syndrone, which is characterized by cleft palate, facial dysmorphology and conotruncal heart defects.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Claudin 5 polyclonal antibody detects endogenous levels of Claudin 5 protein.

Bioworld Molecular Weight: 24 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Claudin 5 on human lung cells lysates using anti-Claudin 5 antibody at 1/500 dilution., Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-Claudin 5 antibody. Counter stained with hematoxylin.

Alternative Name: TMDVCF, CLDN5, Androgen withdrawal and apoptosis induced protein RVP1 like, AWAL, BEC 1, BEC1, Claudin 5 (transmembrane protein deleted in velocardiofacial syndrome), Claudin-5, Claudin5, CLD5, CLDN 5, Cldn5, CPETR L1, CPETRL 1, CPETRL1, TMDVCF, TMVCF, Transmembrane protein deleted in VCFS, Transmembrane protein deleted in velocardiofacial syndrome,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified