ALKBH1 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS7984-50, BS7984-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q13686

Host: Rabbit

Reactivity: Human

Applications: WB IP

All Applications: WB 1:500 - 1:2000
IP 1:50 - 1:200

Background: ALKB protects DNA and RNA against damage from methylating compounds from the environment by directly reversing 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) cytotoxic alkylation lesions in DNA and RNA. The enzymes act by oxidative demethylation, utilizing ferrous iron and alpha-ketoglutarate as cofactors, 2-oxoglutarate as a co-substrate, and molecular oxygen as the oxidizing agent. Deficiencies in DNA and RNA repair in mammals are associated with cancer, neurological disease and developmental defects. ALKB plays a role in resistance to anti-cancer drugs which attempt to damage tumor DNA. Escherichia coli ALKB protein belongs to the superfamily of 2-oxoglutarate- and iron(II)-dependent oxygenases.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: ALKBH1 polyclonal antibody detects endogenous levels of ALKBH1 protein.

Bioworld Molecular Weight: ~ 43 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western Blot (WB) analysis of ALKBH1 polyclonal antibody

Alternative Name: ABH;
ABH1;
alkB;
AlkB, alkylation repair homolog 1 (E. coli);
ALKB1_HUMAN;
ALKBH;
ALKBH1;
Alkylated DNA repair protein alkB homolog 1;
Alkylation repair homolog 1;
Alkylation repair, alkB homolog;
Alpha-ketoglutarate-dependent dioxygenase ABH1;
DNA lyase ABH1;
DNA oxidative demethylase ALKBH1;
hABH;

Immunogen: Recombinant full length Human ALKBH1.

Conjugate: Unconjugated

Modification: Unmodified