p21 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA20745-50, RA20745-100

Citations, Manuals and MSDS Available upon request.

Background: cyclin dependent kinase inhibitor 1A (CDKN1A) Homo sapiens This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lac

Condition: PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

Storage Instructions: -20°C/1 year

Recommended dilutions: Western Blot: 1/500 - 1/2000.IHC-p:1:50-300. Not yet tested in other applications.

Alternative Names: CDKN1A; CAP20; CDKN1; CIP1; MDA6; PIC1; SDI1; WAF1; Cyclin-dependent kinase inhibitor 1; CDK-interacting protein 1; Melanoma differentiation-associated protein 6; MDA-6; p21; YM3453

Applications: WB; IHC-p; IF (paraffin section)

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 1026

Protein MW (KDa): 21

SWISS: P38936

Source: Rabbit

Research Use Only