(-)-Integerrimine, a pyrrolizidine alkaloid, has antiulcerogenic activity. (-)-Integerrimine is also a mutagenic and weakly clastogenic agent in Drosophila.

Product information

CAS Number: 480-79-5

Molecular Weight: 335.39

Formula: C18H25NO5

Chemical Name: (1R, 4E, 6R, 7R, 17R)-4-ethylidene-7-hydroxy-6, 7-dimethyl-2, 9-dioxa-14-azatricyclo[9.5.1.0, ]heptadec-11-ene-3, 8-dione

Smiles: C[C@@H]1C/C(=C\C)/C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@]1(C)O)[C@@H]32

InChiKey: HKODIGSRFALUTA-IKZAEVNJSA-N

InChi: InChI=1S/C18H25NO5/c1-4-12-9-11(2)18(3,22)17(21)23-10-13-5-7-19-8-6-14(15(13)19)24-16(12)20/h4-5,11,14-15,22H,6-10H2,1-3H3/b12-4+/t11-,14-,15-,18-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

(-)-Integerrimine (0.00625-0.05 mM) also must have mutagenic activity in somatic cells of Drosophila. (-)-Integerrimine in general requires cytochrome P450-dependent metabolic activation to exhibit genotoxic activity.

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