Recombinant Human PMM1 Protein (His Tag)

Sizes: 10μg, 50μg

Catalogue Numbers: PKSH032893-10, PKSH032893-50

Citations, Manuals and MSDS Available upon request.

Abbreviation: PMM1

Target Synonym: Phosphomannomutase 1; PMM 1; PMMH-22; PMM1; PMMH22

UNIProt ID: Q92871

Research Areas: Signal Transduction; metabolism;

Target Species: Human

Expression Host: E.coli

Fusion Tag: C-6His

Accession: Q92871

Background: Phosphomannomutase 1 (PMM1) blongs to the eukaryotic PMM family. Phosphomannomutase 1 can catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose which required for a number of critical mannosyl transfer reactions. PMM1 is highly expressed in liver, heart, brain, and pancreas, but lower expression in skeletal muscle. In addition, PMM1 may be responsible for the degradation of glucose-1, 6 bisphosphate in ischemic brain.

Sequence: Met 1-Ala262

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM DTT, pH 8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 30.8 kDa

Observed MW: 49 kDa

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Research Use Only