BRD7-IN-1, a modified derivative of BI7273 (BRD7/9 inhibitor), binds to a VHL ligand via a linker to form a PROTAC VZ185 (VZ185 against BRD7/9 with DC50s of 4.5 and 1.8 nM, respectively).

Product information

CAS Number: 2448414-48-8

Molecular Weight: 467.39

Formula: C22H28Cl2N4O3

Chemical Name: 4-{3,5-dimethoxy-4-[(piperazin-1-yl)methyl]phenyl}-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one dihydrochloride

Smiles: Cl.Cl.CN1C=C(C2=CC(OC)=C(CN3CCNCC3)C(=C2)OC)C2=CC=NC=C2C1=O

InChiKey: VUBFYDKFJHVJDQ-UHFFFAOYSA-N

InChi: InChI=1S/C22H26N4O3.2ClH/c1-25-13-18(16-4-5-24-12-17(16)22(25)27)15-10-20(28-2)19(21(11-15)29-3)14-26-8-6-23-7-9-26;;/h4-5,10-13,23H,6-9,14H2,1-3H3;2*1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 2 mg/mL (4.28 mM; Need ultrasonic). H2O : 100 mg/mL (213.95 mM; Need ultrasonic).

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.