ZDH17 Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA36364-50, RA36364-100

Citations, Manuals and MSDS Available upon request.

Background: catalytic activity:Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.,domain:The DHHC domain is required for palmitoyltransferase activity.,function:Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. May be involved in the NF-kappa-B signaling pathway. Has transforming activity.,miscellaneous:The early and prominent pathology of HD is observed in the medium spiny neurons that project into the globus.,similarity:Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.,similarity:Contains 1 DHHC-type zinc finger.,similarity:Contains 5 ANK repeats.,subunit:Binds HD. This interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease.,tissue specificity:Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney.,

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000

Applications: WB; ELISA

Species Cross-Reactivity: Human; Mouse

GeneID (Human): 23390

Protein MW (KDa): 69

SWISS: Q8IUH5

Source: Rabbit

Research Use Only