(±)-U-50488 hydrochloride is a selective agonist for κ-opioid receptor . The κ-opioid receptor (KOR) is a type of opioid receptor for opioid peptide dynorphin and controls addiction. Also, KOR plays an important role in stress, anxiety, anhedonia, depression and increased drug-seeking behavior. (±)-U-50488 hydrochloride is a selective KOR agonist . In isolated rat DRG neurons, U-50488 (0.3-40 μM) inhibited voltage-independent Ca2+ channel currents. In HeLa cells that didn’t express KOR, U-50488 (20 μM) blocked Ca2+ channels . In rhesus monkeys, U-50488 exhibited potent antinociceptive activity and produced diuresis . U-50488 enhanced contraction of the rabbit vas deferens induced by electrically with IC50 value of 26.5 nM. In mice, U-50488 impaired motor function with ED50 value of 15.3 mg/kg and reduced spontaneous activity . In adult rats, U-50488 increased the threshold required to maintain self-stimulation responding, a depressive-like effect. While, males were significantly more sensitive than females to the threshold-increasing effects .

Product information

CAS Number: 67197-96-0

Molecular Weight: 405.79

Formula: C19H27Cl3N2O

Chemical Name: Benzeneacetamide, 3, 4-dichloro-N-methyl-N-[(1R, 2R)-2-(1-pyrrolidinyl)cyclohexyl]-, hydrochloride (1:1), rel-

Smiles: Cl.CN([C@@H]1CCCC[C@H]1N1CCCC1)C(=O)CC1=CC=C(Cl)C(Cl)=C1 |&1:3,8|

InChiKey: KGMMGVIYOHGOKQ-JAXOOIEVSA-N

InChi: InChI=1S/C19H26Cl2N2O.ClH/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1H/t17-,18-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.