The dosage is 1 mL injected intramuscularly or subcutaneously. Open syringe by twisting or tapping the cap against a hard surface to break the heat weld. Prepare the vaccine by injecting the diluent into the vial containing the desiccated vaccine cake. Shake well. Withdraw entire contents into the syringe. Thoroughly prepare injection site with antiseptic.

Subcutaneous administration: Lift the loose skin behind the neck or behind front leg and insert needle. Inject entire contents of syringe. Do not inject directly into blood vessel (see note below).
Intramuscular administration: Insert needle into muscle of the hind limb (see illustration). Inject entire contents of syringe. Do not inject directly into blood vessel.

IMPORTANT NOTE: Before injecting vaccine pull back slightly on syringe plunger. If blood enters the syringe freely, choose another injection site. For puppies 9 weeks or younger vaccinate healthy puppies at 3-4 week intervals until 16 weeks of age for at least 3 doses. For puppies over 9 weeks and adults give a minimum of 2 doses at 3-4 week intervals. Annual revaccination with a single dose is recommended.